Osteoporose der Wirbelsäule – Mikronährstofftherapie

Menschen mit Osteoporose gehören zu einer Risikogruppe, die anfälliger für einen Mangel folgender Vitalstoffe* ist:

Osteoporose als Mangelsymptom kann ein auf eine unzureichende Versorgung folgender Vitalstoffe* hinweisen:

Im Rahmen der Mikronährstoffmedizin werden zur unterstützenden Therapie von Osteoporose folgende Vitalstoffe* eingesetzt:

Detaillierte Informationen zu den einzelnen Mikronährstoffen finden Sie im DocMedicus Vitalstofflexikon.

Die obigen Vitalstoff-Empfehlungen (Mikronährstoffe) wurden mithilfe des DocMedicus Expertensystems erstellt. Sämtliche Aussagen des Expertensystems sind durch Literatur mit hohen Evidenzgraden belegt.
Für eine Therapieempfehlung wurden nur klinische Studien mit den höchsten Evidenzgraden (Grad 1a/1b und 2a/2b) verwendet, die aufgrund ihrer hohen Aussagekraft die Therapieempfehlung belegen.

Hinweis!
Diese Daten werden in gewissen Zeitabständen aktualisiert.
Das DocMedicus Expertensystem ist stets auf dem aktuellen Stand der Vitalstoff-Forschung. Lassen Sie sich deshalb Ihre persönliche Vitalstoff-Analyse* mithilfe des DocMedicus Expertensystems bei Ihrem Arzt erstellen.

*Makronährstoffe (Kohlenhydrate, Fette, Proteine (Eiweiße)) und Mikronährstoffe (Vitamine, Mineralstoffe, Spurenelemente) sowie weitere Stoffe mit ernährungsspezifischer und physiologischer Wirkung

Vitalstoff-Analyse für den Mann
Vitalstoff-Analyse für die Frau

Männergesundheit – Vitalstoff-Analyse
Frauengesundheit – Vitalstoff-Analyse

Literatur

  1. Mata-Granados José M, Cuenca-Acebedo Rafael, Luque de Castro María Dolores, Quesada Gómez José M. Lower vitamin E serum levels are associated with osteoporosis in early postmenopausal women: a cross-sectional study. J Bone Miner Metab. 2013 Jul; 31, 4: 455-60
  2. Suzuki Atsushi, Kotake Motoko, Ono Yasunaga, Kato Taiya, Oda Naohisa, Hayakawa Nobuki, Hashimoto Shuji, Itoh Mitsuyasu. Hypovitaminosis D in type 2 diabetes mellitus: Association with microvascular complications and type of treatment. Endocr J. 2006 Aug; 53, 4: 503-10
  3. Ozgocmen S, Bulut S, Ilhan N, Gulkesen A, Ardicoglu O, Ozkan Y. Vitamin D deficiency and reduced bone mineral density in multiple sclerosis: effect of ambulatory status and functional capacity. J Bone Miner Metab. 2005;23(4):309-13.
  4. Gür Ali, Colpan Leyla, Nas Kemal, Cevik Remzi, Saraç Jale, Erdogan Ferda, Düz M Zahir. The role of trace minerals in the pathogenesis of postmenopausal osteoporosis and a new effect of calcitonin. J Bone Miner Metab. 2002 Mrz; 20, 1: 39-43
  5. Zheng J, Mao X, Ling J, He Q, Quan J. Low serum levels of zinc, copper, and iron as risk factors for osteoporosis: a meta-analysis. Biol Trace Elem Res. 2014 Jul;160(1):15-23. doi: 10.1007/s12011-014-0031-7. Epub 2014 Jun 8.
  6. Hahn A, Ströhle A, Wolters M. Ernährung. Physiologische Grundlagen, Prävention, Therapie. 4. Auflage, Wissenschaftliche Verlagsgesellschaft, Stuttgart 2023
  7. Braunwald, Fauci, Kasper, Hauser, Longo, Jameson. Harrisons Innere Medizin 1, 15. Auflage. In: Dietel M, Dudenhausen J, Suttorp N. ABW Wissenschaftsverlag, Berlin 2003
  8. Morton D J, Barrett-Connor E L, Schneider D L. Vitamin C supplement use and bone mineral density in postmenopausal women.J Bone Miner Res. 2001 Jan; 16, 1: 135-40
  9. Hall S L, Greendale G A. The relation of dietary vitamin C intake to bone mineral density: results from the PEPI study. Calcif Tissue Int. 1998 Sep; 63, 3: 183-9
  10. Meier C, Woitge HW, Witte K, Lemmer B, Seibel MJ. Supplementation with oral vitamin D3 and calcium during winter prevents seasonal bone loss: a randomized controlled open-label prospective trial. J Bone Miner Res. 2004 Aug;19(8):1221-30. Epub 2004 May 24.
  11. Larsen ER, Mosekilde L, Foldspang A. Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: a pragmatic population-based 3-year intervention study. J Bone Miner Res. 2004 Mar;19(3):370-8. Epub 2003 Dec 22.
  12. Ricci TA, Chowdhury HA, Heymsfield SB, Stahl T, Pierson RN Jr, Shapses SA. Calcium supplementation suppresses bone turnover during weight reduction in postmenopausal women. J Bone Miner Res. 1998 Jun;13(6):1045-50.
  13. Papadimitropoulos E, Wells G, Shea B, Gillespie W, Weaver B, Zytaruk N, Cranney A, Adachi J, Tugwell P, Josse R, Greenwood C, Guyatt G; Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group. Meta-analyses of therapies for postmenopausal osteoporosis. VIII: Meta-analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women. Endocr Rev. 2002 Aug;23(4):560-9. Review.
  14. Rodriguez-Martinez MA, Garcia-Cohen EC. Role of Ca(2+) and vitamin D in the prevention and treatment of osteoporosis. Pharmacol Ther. 2002 Jan;93(1):37-49. Review.
  15. del Puente A, Esposito A, Savastano S, Carpinelli A, Postiglione L, Oriente P. Dietary calcium intake and serum vitamin D are major determinants of bone mass variations in women. A longitudinal study. Aging Clin Exp Res. 2002 Oct;14(5):382-8.
  16. Abitbol V, Mary JY, Roux C, Soule JC, Belaiche J, Dupas JL, Gendre JP, Lerebours E, Chaussade S; Groupe D'etudes Therapeutiques des Affections Inflammatoires Digestives (GETAID). Osteoporosis in inflammatory bowel disease: effect of calcium and vitamin D with or without fluoride. Aliment Pharmacol Ther. 2002 May;16(5):919-27.
  17. Reid IR.The roles of calcium and vitamin D in the prevention of osteoporosis. Endocrinol Metab Clin North Am. 1998 Jun;27(2):389-98. Review.
  18. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997 Sep 4;337(10):670-6.
  19. Di Daniele N, Carbonelli MG, Candeloro N, Iacopino L, De Lorenzo A, Andreoli A. Effect of supplementation of calcium and vitamin D on bone mineral density and bone mineral content in peri- and post-menopause women; a double-blind, randomized, controlled trial. Pharmacol Res. 2004 Dec;50(6):637-41.
  20. Ilich JZ, Brownbill RA, Tamborini L. Bone and nutrition in elderly women: protein, energy, and calcium as main determinants of bone mineral density. Eur J Clin Nutr. 2003 Apr;57(4):554-65. Erratum in: Eur J Clin Nutr. 2003 Jul;57(7):880.
  21. Adams J, Pepping J. Vitamin K in the treatment and prevention of osteoporosis and arterial calcification. Am J Health Syst Pharm. 2005 Aug 1;62(15):1574-81.
  22. Booth SL, Broe KE, Gagnon DR, Tucker KL, Hannan MT, McLean RR, Dawson-Hughes B, Wilson PW, Cupples LA, Kiel DP. Vitamin K intake and bone mineral density in women and men. Am J Clin Nutr. 2003 Feb;77(2):512-6.
  23. Zittermann A. Effects of vitamin K on calcium and bone metabolism. Curr Opin Clin Nutr Metab Care. 2001 Nov;4(6):483-7. Review.
  24. Braam L A J L M, Knapen M H J, Geusens P, Brouns F, Hamulyák K, Gerichhausen M J W, Vermeer C. Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Calcif Tissue Int. 2003 Jul; 73, 1: 21-6
  25. Huang Z-B, Wan S-L, Lu Y-J, Ning L, Liu C, Fan S-W. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015 Mrz; 26, 3: 1175-86
  26. Herrmann M, Widmann T, Herrmann W. Homocysteine - a newly recognised risk factor for osteoporosis. Clin Chem Lab Med. 2005;43(10):1111-7.
  27. Levene CI, Sharman DF, Callingham BA. Inhibition of chick embryo lysyl oxidase by various lathyrogens and the antagonistic effect of pyridoxal. Int J Exp Pathol. 1992 Oct;73(5):613-24.
  28. Biesalski HK, Bischoff SC, Pirlich M, Weimann A (Hrsg.): Ernährungsmedizin. Nach dem Curriculum Ernährungsmedizin der Bundesärztekammer. 5. Auflage. Georg Thieme Verlag, Stuttgart 2017
  29. New SA, MacDonald HM, Campbell MK, Martin JC, Garton MJ, Robins SP, Reid DM. Lower estimates of net endogenous non-carbonic acid production are positively associated with indexes of bone health in premenopausal and perimenopausal women. Am J Clin Nutr. 2004 Jan;79(1):131-8.
  30. Sakhaee K, Maalouf NM, Abrams SA, Pak CY. Effects of potassium alkali and calcium supplementation on bone turnover in postmenopausal women. J Clin Endocrinol Metab. 2005 Jun;90(6):3528-33. Epub 2005 Mar 8.
  31. Marangella M, Di Stefano M, Casalis S, Berutti S, D'Amelio P, Isaia GC. Effects of potassium citrate supplementation on bone metabolism. Calcif Tissue Int. 2004 Apr;74(4):330-5.
  32. Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 1999 Apr;69(4):727-36.
  33. Dimai HP, Porta S, Wirnsberger G, Lindschinger M, Pamperl I, Dobnig H, Wilders-Truschnig M, Lau KH. Daily oral magnesium supplementation suppresses bone turnover in young adult males. J Clin Endocrinol Metab. 1998 Aug;83(8):2742-8.
  34. Hirota T, Hirota K. [Osteoporosis and intake of vitamins] Clin Calcium. 2005 May;15(5):854-7. Review. Japanese.
  35. Hirota T, Hirota K. [Strategies for the prevention of osteoporosis in young and middle aged adults] Clin Calcium. 2004 Nov;14(11):57-62. Review. Japanese.
  36. Katsuyama H, Sunami S, Fukunaga M. [Influence of nutrients intake on bone turnover markers] Clin Calcium. 2005 Sep;15(9):1529-34. Japanese.
  37. Maggio D, Barabani M, Pierandrei M, Polidori MC, Catani M, Mecocci P, Senin U, Pacifici R, Cherubini A. Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab. 2003 Apr;88(4):1523-7.
  38. McCabe LD, Martin BR, McCabe GP, Johnston CC, Weaver CM, Peacock M. Dairy intakes affect bone density in the elderly. Am J Clin Nutr. 2004 Oct;80(4):1066-74.
  39. Nieves JW. Osteoporosis: the role of micronutrients. Am J Clin Nutr. 2005 May;81(5):1232S-1239S. Review.
  40. Schaafsma A, de Vries PJ, Saris WH. Delay of natural bone loss by higher intakes of specific minerals and vitamins. Crit Rev Food Sci Nutr. 2001 May;41(4):225-49. Review.
  41. Turan B, Can B, Delilbasi E. Selenium combined with vitamin E and vitamin C restores structural alterations of bones in heparin-induced osteoporosis. Clin Rheumatol. 2003 Dec;22(6):432-6. Epub 2003 Oct 31.
  42. Weber P. The role of vitamins in the prevention of osteoporosis--a brief status report. Int J Vitam Nutr Res. 1999 May;69(3):194-7. Review.
  43. Lowe NM, Lowe NM, Fraser WD, Jackson MJ. Is there a potential therapeutic value of copper and zinc for osteoporosis? Proc Nutr Soc. 2002 May;61(2):181-5. Review.
  44. Gur A, Colpan L, Nas K, Cevik R, Sarac J, Erdogan F, Duz MZ. The role of trace minerals in the pathogenesis of postmenopausal osteoporosis and a new effect of calcitonin. J Bone Miner Metab. 2002;20(1):39-43.
  45. McCarty MF. Anabolic effects of insulin on bone suggest a role for chromium picolinate in preservation of bone density. Med Hypotheses. 1995 Sep;45(3):241-6. Review.
  46. Rico H, Gomez-Raso N, Revilla M, Hernandez ER, Seco C, Paez E, Crespo E. Effects on bone loss of manganese alone or with copper supplement in ovariectomized rats. A morphometric and densitomeric study. Eur J Obstet Gynecol Reprod Biol. 2000 May;90(1):97-101.
  47. Kruger MC, Coetzer H, de Winter R, Gericke G, van Papendorp DH. Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis. Aging (Milano). 1998 Oct;10(5):385-94.
  48. Harkness LS, Fiedler K, Sehgal AR, Oravec D, Lerner E. Decreased bone resorption with soy isoflavone supplementation in postmenopausal women. J Womens Health (Larchmt). 2004 Nov;13(9):1000-7.
  49. Lydeking-Olsen E, Beck-Jensen JE, Setchell KD, Holm-Jensen T. Soymilk or progesterone for prevention of bone loss--a 2 year randomized, placebo-controlled trial. Eur J Nutr. 2004 Aug;43(4):246-57. Epub 2004 Apr 14.
  50. Chen YM, Ho SC, Lam SS, Ho SS, Woo JL. Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial. J Clin Endocrinol Metab. 2003 Oct;88(10):4740-7.
  51. Khalil Dania A, Lucas Edralin A, Juma Shanil, Smith Brenda J, Payton Mark E, Arjmandi Bahram H. Soy protein supplementation increases serum insulin-like growth factor-I in young and old men but does not affect markers of bone metabolism. J Nutr. 2002 Sep; 132, 9: 2605-8
  52. Ye YB, Tang XY, Verbruggen MA, Su YX. Soy isoflavones attenuate bone loss in early postmenopausal Chinese women: a single-blind randomized, placebo-controlled trial. Eur J Nutr. 2006 Sep;45(6):327-34.
  53. Sun Yiping, Mao Minwei, Sun Lihua, Feng Yingying, Yang Jianfen, Shen Peihua. Treatment of osteoporosis in men using dehydroepiandrosterone sulfate. Chin Med J (Engl). 2002 Mrz; 115, 3: 402-4

Autoren: Dr. med. Werner G. Gehring
Letzte Aktualisierung: 27.01.2025

Maridav – stock.adobe.com

Teilen
Drucken Zurück