Chronisches Müdigkeitssyndrom (Chronic-Fatique-Syndrom; CFS) – Mikronährstofftherapie

Chronisches Müdigkeitssyndrom als Mangelsymptom kann ein auf eine unzureichende Versorgung folgender Vitalstoffe* hinweisen:

Im Rahmen der Mikronährstoffmedizin werden zur unterstützenden Therapie beim chronischem Müdigkeitssyndrom folgende Vitalstoffe* eingesetzt:

Detaillierte Informationen zu den einzelnen Mikronährstoffen finden Sie im DocMedicus Vitalstofflexikon.

Die obigen Vitalstoff-Empfehlungen (Mikronährstoffe) wurden mithilfe des DocMedicus Expertensystems erstellt. Sämtliche Aussagen des Expertensystems sind durch Literatur mit hohen Evidenzgraden belegt.
Für eine Therapieempfehlung wurden nur klinische Studien mit den höchsten Evidenzgraden (Grad 1a/1b und 2a/2b) verwendet, die aufgrund ihrer hohen Aussagekraft die Therapieempfehlung belegen.

Hinweis!
Diese Daten werden in gewissen Zeitabständen aktualisiert.
Das DocMedicus Expertensystem ist stets auf dem aktuellen Stand der Vitalstoff-Forschung. Lassen Sie sich deshalb Ihre persönliche Vitalstoff-Analyse* mithilfe des DocMedicus Expertensystems bei Ihrem Arzt erstellen.

*Makronährstoffe (Kohlenhydrate, Fette, Proteine (Eiweiße)) und Mikronährstoffe (Vitamine, Mineralstoffe, Spurenelemente) sowie weitere Stoffe mit ernährungsspezifischer und physiologischer Wirkung

Vitalstoff-Analyse für den Mann
Vitalstoff-Analyse für die Frau

Männergesundheit – Vitalstoff-Analyse
Frauengesundheit – Vitalstoff-Analyse

Literatur

  1. Joustra ML, Minovic I, Janssens KAM, Bakker SJL, Rosmalen JGM. Vitamin and mineral status in chronic fatigue syndrome and fibromyalgia syndrome: A systematic review and meta-analysis. PLoS One. 2017 Apr 28;12(4):e0176631.
  2. Miwa K, Fujita M. Fluctuation of serum vitamin E (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome. Heart Vessels. 2010 Jul;25(4):319-23.
  3. Jacobson W, Saich T, Borysiewicz L K, Behan W M, Behan P O, Wreghitt T G. Serum folate and chronic fatigue syndrome. Neurology. 1993 Dez; 43, 12: 2645-7.
  4. Plioplys A V, Plioplys S. Serum levels of carnitine in chronic fatigue syndrome: clinical correlates. Neuropsychobiology. 1995 Mrz; 32, 3: 132-8.
  5. Maes M, Mihaylova I, Leunis JC. In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. Neuro Endocrinol Lett. 2005 Dec;26(6):745-51.
  6. Barnish M, Sheikh M, Scholey A. Nutrient Therapy for the Improvement of Fatigue Symptoms. Nutrients. 2023 Apr 30;15(9):2154.
  7. Bjørklund G, Dadar M, Pen JJ, Chirumbolo S, Aaseth J. Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach. Biomed Pharmacother. 2019 Jan;109:1000-1007.
  8. Maric D, Brkic S, Tomic S, Novakov Mikic A, Cebovic T, Turkulov V. Multivitamin mineral supplementation in patients with chronic fatigue syndrome. Med Sci Monit. 2014 Jan 14;20:47-53.
  9. Sarris J, Cox KH, Camfield DA, Scholey A, Stough C, Fogg E, Kras M, White DJ, Sali A, Pipingas A. Participant experiences from chronic administration of a multivitamin versus placebo on subjective health and wellbeing: a double-blind qualitative analysis of a randomised controlled trial. Nutr J. 2012 Dec 14;11:110.
  10. Witham MD, Adams F, McSwiggan S, Kennedy G, Kabir G, Belch JJF, et al. Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome - A randomised controlled trial. Nutr Metab Cardiovas Dis. 2015; 25: 287–94.
  11. Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, Zachrisson O, Gottfries CG. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015 Apr 22;10(4):e0124648.
  12. Puri BK, Holmes J, Hamilton G. Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes. Int J Clin Pract. 2004 Mar;58(3):297-9.
  13. Behan P O, Behan W M, Horrobin D. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Acta Neurol Scand. 1990 Sep; 82, 3: 209-16.
  14. Williams J, Kellett J, Roach PD, McKune A, mellor D, Thomas J, Naumovski N (2016). L-Theanine as a Functional Food Additive: Its Role in Disease Prevention and Health Promotion. Beverages 2(13): 1-16.
  15. Griesbrecht T, Rycroft JA, Rowson MJ, De Bruin EA (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci 13(6): 283-290.
  16. Jonkees BJ, Hommel B, Kühn S, Colzato L (2015). Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands-A review. J Psychiatr Res 70: 50-57.
  17. Vermeulen Ruud C W, Scholte Hans R. Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. Psychosom Med. 2004 Mrz; 66, 2: 276-82.
  18. Plioplys A V, Plioplys S. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. Neuropsychobiology. 1997 Sep; 35, 1: 16-23.
  19. Bentler Suzanne E, Hartz Arthur J, Kuhn Evelyn M. Prospective observational study of treatments for unexplained chronic fatigue. J Clin Psychiatry. 2005 Mai; 66, 5: 625-32.
  20. Castro-Marrero J, Segundo MJ, Lacasa M, Martinez-Martinez A, Sentañes RS, Alegre-Martin J. Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021 Jul 30;13(8):2658.
  21. Tsai IC, Hsu CW, Chang CH, Tseng PT, Chang KV. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Pharmacol. 2022 Aug 24;13:883251.
  22. EMA Assesment Report on Rhodiola rosea L., rhizoma et radix 2012: EMA/HMPC/232100/2011
  23. Olsson EMG, von Schéele B, Panossian A (2009). randomised, double-blind, placebocontrolled, parallel-group study of the standardised extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stressrelated fatigue. Planta Med. 75 (2): 105-112.
  24. Spasov AA, Wikman GK, Mandrikov, VB, Mironova IA, Neumoin VV (2000). A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 7(2): 85-89.
  25. Shevtsov VA, Zholus BI, Shervarly VI, Vol'skij VB, Korovin, YP, Khristich MP, Roslyakova NA, Wikman G (2003). A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 10: 95-105.
  26. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H (2000). Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty Phytomedicine 2000; 7(5): 356-371.
  27. Cropley M, Banks AP, Boyle J (2015). The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytotherapy Research 29: 1934-1939.
  28. Olsson Erik M, von Schéele Bo, Panossian Alexander G. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009 Feb; 75, 2: 105-12.
  29. Coe S, Cossington J, Collett J, Soundy A, Izadi H, Ovington M, Durkin L, Kirsten M, Clegg M, Cavey A, Wade DT, Palace J, DeLuca GC, Chapman K, Harrison JM, Buckingham E, Dawes H. A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis. J Neurol Neurosurg Psychiatry. 2019 May;90(5):507-513.